第一部分 奋斗历程

药物化学家张礼和院士

第二部分 学术贡献

一、张礼和院士的学术成就及学术思想

二、张礼和院士的主要学术论文

1，2，4-三嗪类化合物的研究——Ⅱ.3-甲硫基-5-羟基-6-甲基-1，2，4-三嗪的不正常甲苯磺酰化反应

羟基含氮杂环化合物的对甲苯磺酰化反应

Deglyco-bleomycin Degradation of DNA and Formation of a Structurally Unique Fe（Ⅱ）·CO Complex

Deglycobleomycin：Total Synthesis and Oxygen Transfer Properties of an Active Bleomycin Analogue

Total Synthesis of Bleomycin

环状核苷酸的磷酸酯、磷酰胺的合成及其生物活性的研究

T4 RNA Ligase Mediated Preparation of Novel “Chemically Misacylated” tRNAPheS

环状核苷酸衍生物的合成

腺嘌呤核苷的环磷酰化反应

DNA Strand Scission by Bleomycin：Catalytic Cleavage and Strand Selectivity

Synthesis of 9-β-D-（Xylofuranosyl） adenine from Adenosine

Synthesis of（3’-5’），（2’-5’）-linked Di- and Tri-adenylyl Methylphosphonate Analogs

Evidence for the Rate-Limiting Departure of the 5’-Oxygen in Nonenzymatic and Hammerhead Ribozyme-Catalyzed Reactions

Ribozyme Mechanism Revisited：Evidence against Direct Coordination of a Mg2＋ Ion with the pro-R Oxygen of the Scissile Phosphate in the Transition State of a Hammerhead Ribozyme-Catalyzed Reaction

Synthesis of Lactosyl Phosphate Diester Derivatives of Nucleosides

Explanation by the Double-metal-ion Mechanism of Catalysis for the Differential Metal-ion Effects on the Cleavage Rates of 5’-oxy and 5’-thio Substrates by a Hammerhead Ribozyme

Stereoselective Synthesis of 4-deo xy-4-nucleobase-2，5-anhydro-L-mannitol Derivatives

Synthesis of 2-C-（4-aminocarbonyl-2-thiazoyl）-1，4-anhydro-L-xylitols and Their Fluoro Derivatives

Studies on the Synthesis and Properties of New PNA Analogs Consisting of Land D-Lysine Backbones

Synthesis of 5-substituted-3-[（2’S，3’S）-3’-hydroxy-2’-hydroxymethyltetrahydrofuran-3’-y1]-1，2，4-oxadiazoles and Their Epimers

Hybrid Characteristics of O1igonucleotides Consisting of Isonucleoside 2’，5’-anhydro-3’-deo xy-3’-（thymin-1-yl）-D-mannitol with Different Linkage Modes

Synthesis of Antisense Oligonucleotide-Peptide Conjugate Targeting to GLUT-1 in HepG-2 and MCF-7 Cells

Syntheses and Calcium-Mobilizing Evaluations of N1-Glycosyl-Subsituted Stable Mimics of Cyclic ADP-Ribose

Studies on the Synthesis of a G-rich Octaoligoisonucleotide（isoT） 2（isoG）4（isoT）2 by the Phosphotriester Approach and Its Formation of G-quartet Structure

Signal Peptide Mimics Conjugated to Peptide Nucleic Acid：A Promising Solution for Improving Cell Membrane Permeability

A Concise Method for the Preparation of Peptide and Arginine-Rich Peptide-Conjugated Antisense Oligonucleotide

从生物有机化学到化学生物学

Synthesis and Biological Evaluation of Novel Membrane-Permeant Cyclic ADP-Ribose Mimics：N1-[（5″-O-Phosphorylethoxy）methyl]-5’-phosphorylinosine 5’，5″-Cyclicpyrophosphate （cIDPRE） and 8-Substituted Derivatives

Properties of Isonucleotide-Incorporated Oligodeoxynucleotides and Inhibition of the Expression of Spike Protein of SARS-CoV

A Minimal Structural Analogue of Cyclic ADP-ribose——Synthesis and Calcium Release Activity in Mammalian Cells

Synthesis and Agonist Activity of Cyclic ADP-Ribose Analogues with Substitution of the Northern Ribose by Ether or Alkane Chains

Structural Insights into the Effect of Isonucleosides on B-DNA Duplexes Using Molecular-dynamics Simulations

Studies on Aminoisonucleoside Modified siRNAs： Stability and Silencing Activity

Three-dimensional Structure of HIV-1 VIF Constructed by Comparative Modeling and the Function Characterization Analyzed by Molecular Dynamics Simulation

Generation of shRNA Pool Library：A Revision of the Biological Technique from the Viewpoint of Chemistry

A Convenient Preparation of 5-Iodo-1，4-disubstituted-1，2，3-triazole：Multicomponent One-Pot Reaction of Azide and Alkyne Mediated by CuI-NBS

Chemical Biology in China Takes on Signal Transduction

Solid-phase Synthesis and Evaluation of TAR RNA Targeted β-carboline-nucleoside Conjugates

CD38/cADPR/Ca2＋ Pathway Promotes Cell Proliferation and Delays Nerve Growth Factor-induced Differentiation in PC12 Cells

A Novel Membrane-permeant cADPR Antagonist Modified in the Pyrophosphate Bridge

Novel Nucleobase-simplified Cyclic ADP-ribose Analogue：A Concise Synthesis and Ca2-mobilizing Activity in T-lymphocytes

Trifluoromethylated Cyclic-ADP-ribose Mimic：Synthesis of 8-trifluoromethyl-N1-[（5″-O-phosphorylethoxy） methyl]-5’-O-phosphorylinosine-5’，5″-cyclic Pyrophosphate （8-CF3-cIDPRE） and Its Calcium Release Activity in T Cells

Catalysis-Based Inhibitors of the Calcium Signaling Function of CD38

A Novel Fluorescent Cell Membrane-permeable Caged Cyclic ADP-ribose Analogue

Strand Antagonism in RNAi：an Explanation of Differences in Potency between Intracellularly Expressed siRNA and shRNA

Synthesis and Properties of Novel L-isonucleoside Modified Oligonucleotides and siRNAs

A Cell Permeable NPE Caged ADP-Ribose for Studying TRPM2

Studies on CD38 Inhibitors and Their Application to cADPR-Mediated Ca2＋Signaling

三、主要学术著作

MEDICINAL CHEMISTRY OF NUCLEIC ACIDS

化学生物学进展

以核酸为作用靶的药物研究

四、张礼和院士学术年表

张礼和院士论文目录

张礼和院士主要学术著作目录

张礼和院士主要奖项目录

第三部分 治学之道

锲而不舍 金石可镂——记北医大药学院院长张礼和教授

攀登药化科学高峰的人——记中科院院士、药物化学家张礼和

张礼和：平平常常学者心

张礼和：为祖国药学事业耕耘的人

张礼和：走在“药学”的路上

张礼和：院士潜心药物学

医药科技发展需建长效激励机制——张礼和院士谈“中国药学会科学技术奖”

用化学方法研究生命过程

生物医药产业：跟踪创新更实际

第四部分 大师风范

科学家的良心与责任——访北京大学药学院张礼和院士

张礼和：“教学和科研都马虎不得”

言传身教育桃李——记中国科学院院士、北京大学医学部张礼和教授

张礼和院士受聘为南开大学杨石先讲座教授

10人获“北京市人民教师”称号

张礼和院士获“北京市人民教师”荣誉称号

2012北京市人民教师奖：张礼和教授主要事迹

张礼和：惜守良心

用化学方法研究生命过程的人——张礼和

北京大学药学院张礼和院士访问沈阳药科大学

张礼和院士：多给点时间 为青年科学家“减负”

张礼和院士2012年9月6日在北京市庆祝教师节大会上的发言

张礼和：院士潜心药物学

张礼和院士谈创新型人才

张礼和院士应邀在基因化学与化学基因组合论坛上作报告

稳扎稳打攻药学，戒骄戒躁求创新——药学院张礼和院士奖学金颁奖仪式暨大学生应具有的学术精神和国际视野讲座

张礼和院士：医药创新人才的培养

张礼和院士等四位专家来我校讲学

北京大学张礼和院士来武汉大学化学与分子科学学院讲学

张礼和院士来沈阳药科大学作学术报告

北京大学医学部张礼和院士前来合肥微尺度物质科学国家实验室进行学术交流与访问

张礼和院士访问武汉大学药学院

张礼和院士莅临我院 逸仙化学论坛开讲

第五部分 社会影响

张礼和：“中国不能没有具有自己知识产权的新药”

张礼和院士获2011年中国化学会有机合成发展促进奖

张礼和院士喜获“Nagai-Hisamitsu杰出科学家奖”

共攀生物医药新高峰——张礼和院士访谈

张礼和院士赴长春应用化学所作报告

张礼和院士：我们制造了不少敌人

张礼和院士访问国家化合物样品库

张礼和与江雷院士莅临福建物构所参观考察

北京大学创新药物研究院

全国科学技术名词审定委员会

第六部分 人生风采