Introduction

PART Ⅰ

Chapter Ⅰ．Degenerative and Regressive Disturbances of Cells and Tissues

Ⅰ．Introduction

Ⅱ．Degenerative and Infiltrative Changes

A．Cloudy Swelling and Vacuolar Degeneration

B．Fatty Deposition

C．Hyaline Degenerations

D．Amyloidosis

E．Mucoid and Colloid Degenerations

F．Glycogenic Infiltration

Ⅲ．Regressive Disturbances

A．Necrosis

B．Autolysis and Putrefaction

References

Chapter Ⅱ．Inflammation

Ⅰ．Introduction

Ⅱ．The Vascular Phenomena of Acute Inflammation

A．Lewis＇＂Triple Response＂

B．Microscopic Changes

C．Mechanisms of Vascular Changes in Acute Inflammation

Ⅲ．The Inflammatory Exudate

A．Formation of the Exudate

B．Fluid Component of the Inflammatory Exudate

C．Cellular Components of the Inflammatory Exudate

D．Types of Inflammation

Ⅳ．Biochemistry of Inflammation

A．Humoral Mediators in Inflammation

B．Biochemical Changes in Inflamed Tissues

Ⅴ．Endocrine Control of Inflammation

Ⅵ．Biology of Inflammation

References

Chapter Ⅲ．Repair，Regeneration and Tissue Transplantation

Ⅰ．Introduction

Ⅱ．Repair

A．Normal Wound Healing

B．Abnormal Wound Healing

Ⅲ．Regeneration

A．Classification of Tissues

B．Regeneration of Some Special Tissues

C．Stimulus for Regeneration

Ⅳ．Tissue Transplantation

A．General Principles of Tissue Transplantation

B．Some Practical Uses of Tissue Transplantation

References

Chapter Ⅳ．Disturbances of Growth and Differentiation of Tissues

Ⅰ．Introduction

Ⅱ．Disturbances of Growth

A．Aplasia，Agenesia and Hypoplasia

B．Atrophy

C．Hyperplasia and Hypertrophy

Ⅲ．Disturbances in Differentiation

A．Metaplasia

B．Anaplasia

C．Nomicoplasia

References

Chapter Ⅴ．General Pathology of Tumors

Ⅰ．Introduction

Ⅱ．Definition，Nomenclature and Classification

A．Definition

B．Nomenclature

C．Classification

Ⅲ．The Etiology of Tumors

A．Experimental Studies

B．The Significance of Experimental Studies in Human Carcinogenesis

C．Clinical Studies

D．Theories on the＂Cause＂of Cancer

Ⅳ．Anatomy，Physiology and Biochemistry of Tumors

A．Anatomy of Tumors

B．Physiology of Tumors

C．Biochemistry of Tumors

Ⅴ．The Dissemination of Tumors

A．Invasion

B．Metastasis

C．Difficulties in Determining Route of Neoplastic Dissemination

D．The Single，Isolated Metastasis

E．Frequency and Distribution of Metastases

F．Transplantation of Tumors

Ⅵ．Diagnosis

A．Biopsy

B．Histologic Diagnosis of Cancer

C．Complications of Biopsy

D．Exfoliative Cytology

E．The Study of the Surgical Specimen

References

PART Ⅱ

Chapter Ⅵ．General Pathology of Connective Tissues

Ⅰ．Introduction

Ⅱ．Organization of Connective Tissues

A．Morphology and Biochemistry

B．Physiology and Functions

Ⅲ．Elementary Lesions of Connective Tissues

A．Elementary Lesions

B．Hypersensitivity and the Connective Tissues

Ⅳ．Diffuse Collagen Diseases

A．A Concept

B．General Pathology

C．Etiology and Pathogenesis

Ⅴ．Heritable Disorders of Connective Tissues

A．Marfan＇s Syndrome

B．Ehlers-Danlos Syndrome

C．Osteogenesis Imperfecta

D．Pseudoxanthoma Elasticum

E．Hurler＇s Syndrome

References

Chapter Ⅶ．General Pathology of the Host-Parasite Relation

Ⅰ．Introduction

Ⅱ．Defense Mechanisms of the Host

A．Local Defense Mechanisms

B．Systemic Defense Mechanisms

C．Concept of Immunity

Ⅲ．Aggressive Mechanisms of the Parasite

A．Pathogenicity and Virulence

B．Aggressive Mechanisms of Bacteria，Rickettsiae，Viruses and Fungi

C．Aggressive Mechanisms of Animal Parasites

D．Parasitic Associations

Ⅳ．The Host-Parasite Relation

A．Types of Host-Parasite Relation

B．Establishment

C．Factors Influencing，the Host-Parasite Relation

D．Nonspecific Reactions of the Host

Ⅴ．Chemotherapy

A．Definition

B．Selective Toxicity

C．Mechanism of Action

D．Resistance

E．Control of Chemotherapy in the Laboratory

F．The Host-Parasite Relation

References

Chapter Ⅷ．General Pathology of the Immune Response

Ⅰ．Introduction

Ⅱ．Antigens and Antibodies

A．Nature of Antigens

B．Nature of Antibodies

C．Antigen-Antibody Reaction

Ⅲ．Hypersensitivity

A．Types of Hypersensitivity

B．Hypersensitivity and Immunity

C．Autoimmunity and Disease

D．Biology of the Immune Response

References

Chapter Ⅸ．General Pathology of Body Fluids and Electrolytes

Ⅰ．Introduction

Ⅱ．Distribution，Composition and Exchange of Body Fluids

A．Distribution of Water in the Organism

B．Composition of Body Fluids

C．The Exchange of Fluids in the Body

Ⅲ．Control of Volume and Concentration of Body Fluids

A．Volume

B．Concentration

C．Integration of Mechanisms Regulating Volume and Concentration of Body Fluids

Ⅳ．Pathologic Changes in Volume and Concentration of Body Fluids

A．Changes in Volume of Body Fluids

B．Changes in Concentration of Body Fluids

C．Edema

Ⅴ．Regulation of H+Ion Equilibrium

A．Basic Principles

B．Physicochemical Regulation

C．Physiologic Regulation

Ⅵ．Disturbances in the Equilibrium of the H+Ion

A．Acidosis

B．Alkalosis

References

Chapter Ⅹ．General Pathology of Metabolism and Nutrition

Ⅰ．Introduction

Ⅱ．Normal Metabolism

A．Energy Metabolism

B．Intermediary Metabolism

C．The Common Metabolic Cycle

Ⅲ．Disturbances of Metabolism

A．Disturbances in Intermediary Metabolism

B．Inborn Errors of Metabolism

C．The Metabolic Response to Trauma

Ⅳ．Nutrition

A．Normal Food Requirements

B．Disturbances of Nutrition

References

Epilogue．The Nature of Disease

Ⅰ．The Beginning of the Story，or The Magical Concept of Disease

Ⅱ．The Hellenic Contribution，or The Birth of Reason

Ⅲ．Galenic Interlude

Ⅳ．The Medieval Period，or The Reign of Dogma and Unreason

Ⅴ．Paracelsus

Ⅵ．From the Renaissance to Claude Bernard

Ⅶ．Bernard，Virchow and Cannon，or The Modern Concept of Disease

INDEX