SECTION Ⅰ CANCER OF THE ECTOCERVIX

1．DIAGNOSTIC METHODS

Introduction

Cytology

Karyology

Schiller Test

Colposcopy

Colpomicroscopy

2．THE NORMAL AND PATHOLOGICAL APPEARANCES OF THE ECTOCERVIX GIVEN BY THE DIFFERENT METHODS

Introduction

Normal Pictures

Nonmalignant Patterns

Erosion and Ectropion

Squamous Metaplasia

Colpitis

Vaginal Trichomoniasis

Polyp

The Ectocervix During the Menopause

The Ectocervix During Pregnancy

Vaginal Prolapse

Precancerous and Cancerous Conditions

Leukoplakia

Base of Leukoplakia

Mosaic Leukoplakia

Papillary Base

Erosio Vera (True Ulcer)

Red Zone

Iodine-negative，Sharply-demarcated Zones

Carcinoma

Remarks on Carcinoma In Situ

Remarks on Invasive Carcinoma and Its Recurrences

3．MORPHOLOGICAL DETERMINATION OF THE RADIOCURABILITY OF CARCINOMA OF THE ECTOCERVIX

Introduction

Radiation Lesions of the Various Tissues

Radiation Lesions of the Chromosomes

Radiation Cell Changes on the Cancerous and Normal Ectocervix

Radiation Cell Changes on Endocervical Glandular Epithelium

Lesions of the Bladder，Ovaries and Pelvic Lymph Nodes，caused by Radiotherapy of Carcinoma of the Ectocervix

Tests of Radiocurability

Changes Produced by High Voltage and Isotope Therapies

4．HISTOCHEMICAL INVESTIGATIONS

Introduction

Carbohydrates

Nucleic Acids

Enzymes

Amount of Beta-glucuronidase in the Vaginal Fluid

Techniques

5．HISTOPHYSICAL INVESTIGATIONS

Introduction

Histophotometric Technique

Ultraviolet Spectrophotometry

Ultraviolet Microspectrography

Phase Contrast Microscopy

Interference Microscopy

Fluorescence Microscopy

The Cytoanalyzer

6．HORMONAL INVESTIGATIONS

Introduction

Estrogens

Progesterone

Androgens

Cytological Determination of the Hormonal State With Particular Reference of Physiological，Radiation-induced and Surgical (by Oophorectomy，Adrenalectomy and Hypophysectomy) Menopause

Cytohormonal Diagnosis of Ovarian Dysfunctions

Modifications Induced by Hormones on the Vaginal Epithelium

Correlations Between Vaginal Cytology and the Level of Urinary Estrogens

7．CONSIDERATIONS ON ENDOCRINE SURGERY

Introduction

Ovario-adrenalectomy

Surgical Hypophysectomy

Isotopic Hypophysectomy

Behavior of Urinary Steriods After Endocrine Surgery

Persistence of Hormonal Activity After Endocrine Surgery

SECTION Ⅱ CANCER OF THE ENDOCERVIX AND ENDOMETRIUM

8．CANCER OF THE ENDOCERVIX

Introduction

Histology of the Endocervix

The Cyclic Changes of the Cervical Mucus

Cytology of the Cervical Canal

Phase Contrast Microscopy of Endocervical Cells

Non-neoplastic Pictures of the Endocervix

Neoplastic Pictures of the Endocervix

9．CANCER OF THE ENDOMETRIUM

Introduction

Histology of the Normal Endometrium

Exfoliative Cytology of the Normal and Pathological Endometrium

Phase Contrast Microscopy of the Endometrial Cells

Histochemistry of the Normal and Abnormal Endometrium and of Adenocarcinoma of the Endometrium

Non-neoplastic Histological Pictures of the Endometrium

Histological Pattern of Carcinomatous Endometrium

10．CYTOLOGIC DIAGNOSIS OF METASTASES FROM CARCINOMA OF THE ECTOCERVIX AND ENDOMETRIUM

Introduction

Pulmonary Cytodiagnosis

Urologic Cytodiagnosis

Cytology of Pleural and Peritoneal Effusions

Detection of Neoplastic Cells in the Peripheral Blood

SECTION Ⅲ ELECTRON MICROSCOPY ON CELLS OF THE PORTIO AND ENDOMETRIUM

11．CELLULAR ULTRASTRUCTURE

Introduction

Cellular Ultrastructure and the Functional Significance of the Various Cell Constituents

Differences Between Normal and Malignant Cells Under the Electron Microscopy

Technique of Electron Microscopy

12．ELECTRON MICROSCOPY ON CELLS OF THE ECTOCERVIX

Introduction

Normal Ectocervix

Carcinoma of the Ectocervix

Electron Microscopy of Carcinoma of the Ectocervix after Irradiation

13．ELECTRON MICROSCOPY ON CELLS OF THE ENDOMETRIUM

Introduction

Normal Endometrium

Carcinoma of the Endometrium

Modifications Induced by Synthetic Progestogens on Endometrium

Conclusions

14．REMARKS ON ULTRASTRUCTURAL-BIOCHEMICAL CHANGES IN NEOPLASTIC CELLS AND THEIR IMPLICATIONS FOR CARCINOGENESIS，DIFFERENTIATED AND UNDIFFERENTIATED NEOPLASMS，AND VARIOUS DEGREES OF MORPHOLOGICAL ATYPIA IN NEOPLASTIC CELLS

SECTION Ⅳ THE SENILE CERVIX AND ENDOMETRIUM EXAMINED WITH THE LIGHT AND ELECTRON MICROSCOPES

15．THE SENILE CERVIX AND ENDOMETRIUM

Introduction

Light Microscope Examination of Senile Cells

The Senile Ectocervix Examined by Means of the Electron Microscope

The Senile Endometrium Examined by Means of the Electron Microscope

The Nuclei of the Senile Ectocervix and Endometrium

Discussion

Conclusions and Prospects for Future Research in the Study of the Senile Cells．Role of Senility in the Carcinogenesis

SECTION Ⅴ FINAL CONSIDERATIONS AND SYNOPSIS OF THE ORIGINAL CONTRIBUTIONS

16．FINAL CONSIDERATIONS

Synopsis of the Original Contributions

BIBLIOGRAPHY

Miscellanea

Vaginal Cytology

Colposcopy

Pathology of the Ectocervix

Pregnancy

Radiation-induced Changes in Various Tissues

Histochemistry

Histophysics

Hormonal Evaluation

Endocrine Therapy of Cancer

Pathology of the Endocervix

Pathology of the Endometrium

Cytodiagnosis of Metastases from Uterine Cancer and Detection of Tumoral Cells in Circulating Blood

Functional Biochemistry of Cell Structures

Electron Microscopy

Senile Changes in Cells

Authors Index

Analytical Index