1．INTRODUCTION

Technic for Biopsy

Limitations of Histologic Diagnosis

2．EMBRYOLOGY OF THE SKIN

The Epidermis

The Dermis

3．HISTOLOGY OF THE SKIN

The Epidermis

The Epidermal Appendages

The Dermis

4．LABORATORY METHODS

Fixation,Processing and Staining

Histochemical Staining

Polariscopic Examination

5．MORPHOLOGY OF THE MESODERMAL CELLS

Myeloid Group

Lymphoid Group

Reticulohistiocytic Group

Plasma Cells

Mast Cells

6．CONGENITAL DISEASES(GENODERMATOSES)

Ichthyosis

Ichthyosis Vulgaris

Ichthyosis Congenita

Congenital Ichthyosiform Erythroderma

Keratosis Palmaris et Plantaris

Keratosis Punctata Palmaris et Plantaris

Pachyonychia Congenita

Dyskeratosis Congenita

Porokeratosis Mibelli

Xeroderma Pigmentosum

Congenital Ectodermal Defect

Rothmund＇s Syndrome(Poikiloderma Congenitale),Werner＇s Syndrome(Progeria of Adults)and progeria of Children

Epidermolysis Bullosa

Darier＇s Disease(Keratosis Follicularis)

Familial Benign Chronic Pemphigus

Acrokeratosis Verruciformis

Pseudoxanthoma Elasticum

Juvenile Elastoma(Nevus Elasticus)

Cutis Hyperelastica(Ehlers-Danlos Syndrome)

Urticaria Pigmentosa

Incontinentia Pigmenti

7．NONINFECTIOUS VESICULAR AND BULLOUS DISEASES

Dermatitis-Eczema

Dermatopathic Lymphadenitis

Miliaria

Pompholyx(Dyshidrotic Eruption)

Erythema Toxicum Neonatorum

Pemphigus

Pemphigus Vulgaris

Pemphigus Vegetans

Pemphigus Foliaceus

Pemphigus Erythematosus

Bullous Pemphigoid

Benign Mucous-Membrane Pemphigoid(Cicatricial Pemphigoid,Pemphigus Conjunctivae)

Erythema Multiforme

Dermatitis Herpetiformis

Subcorneal Pustular Dermatosis

Burn

8．NONINFECTIOUS INFLAMMATORY DISEASES

Urticaria

Erythema Annulare Centrifugum

Prurigo Nodularis

Erythema Nodosum

Nodular Vasculitis

Psoriasis

Pustular Psoriasis,Acrodermatitis Continua,Impetigo Herpetiformis

Reiter＇s Disease

Pustulosis Palmaris et Plantaris(Pustular Bacterid)

Parapsoriasis

Pityriasis Varioliformis Acuta

Pityriasis Rosea

Lichen Planus

Lichen Nitidus

Lichen Striatus

Pityriasis Rubra Pilaris

Granuloma Faciale

Erythema Elevatum Diutinum

Granuloma Annulare

Subcutaneous Nodules of Rheumatic Fever and Rheumatoid Arthritis

Acrodermatitis Chronica Atrophicans

Radiodermatitis

Polymorphous Light Eruption(Solar Dermatitis)

Acne Vulgaris

Acne Varioliformis(Acne Necrotica Miliaris)

Acne Rosacea

Fox-Fordyce Disease

Hidrocystoma

Alopecia Areata

Alopecia Cicatrisata(Pseudopelade Brocq)

Alopecia Mucinosa

Purpura

Noninflammatory Purpura

Inflammatory Purpura(Vasculitis)

Purpura Pigmentosa Chronica(Majocchi-Schamberg)

Relapsing Febrile Nodular Nonsuppurative Panniculitis(Weber-Christian Disease)

Sclerema Neonatorum

Hereditary Edema of the Legs(Milroy＇s Disease)

Chondrodermatitis Helicis and Anthelicis

Scabies

Arthropod Bites

Lichen Urticatus(Papular Urticaria)

Foreign-Body Granulomas

Lipid Granuloma(Paraffinoma)

Tattoo Granuloma

Silica Granuloma

Zirconium Granuloma

Beryllium Granuloma

Swimming-Pool Granuloma

9．ERUPTIONS DUE TO DRUGS

Fixed Drug Eruption

Quinacrine Hydrochloride(Atabrine)Dermatitis

Exfoliative Dermatitis Due to Drugs

Hydralazine(Apresoline)Eruption

Bromoderma

Iododerma

Argyria

Chrysiasis

Arsenical Keratosis and Carcinoma

10．DEGENERATIVE DISEASES

Senile Degeneration

Elastosis Perforans Serpiginosa(Miescher)

Hyperkeratosis Follicularis in Cutem Penetrans(Kyrle)

Lichen Sclerosus et Atrophicus

Kraurosis Vulvae

Balanitis Xerotica Obliterans

Striae Distensae

Macular Atrophy(Anetoderma)

Atrophia Alba(Milian)

Atrophoderma Reticulatum(Folliculitis Ulerythematosa Reticulata)

Colloid Milium(Colloid Degeneration of the Skin)

11．BACTERIAL DISEASES

Impetigo

Erysipelas

Folliculitis(Impetigo Bockhart,Furuncle,Folliculitis Barbae)

Folliculitis Keloidalis(Dermatitis Papillaris Capillitii)

Hidradenitis Suppurativa

Pyoderma Gangrenosum(Chronic Undermining Burrowing Ulcer)

Aphthosis

Meningococcemia(Waterhouse-Friderichsen Syndrome)

Tuberculosis

Primary Tuberculosis

Reinfection Tuberculosis

Sarcoidosis

Cheilitis Granulomatosa

Leprosy

Diphtheria of the Skin

Anthrax

Tularemia

Chancroid

Granuloma Inguinale

Rhinoscleroma

12．SPIROCHETAL DISEASES

Syphilis

Yaws(Frambesia Tropica)

Pinta

13．FUNGAL DISEASES

Dermatophytosis(Tinea)

Moniliasis

North American Blastomycosis(Gilchrist＇s Disease)

South American Blastomycosis(Paracoccidioidomycosis)

Chromoblastomycosis

Cryptococcosis(Torulosis)

Coccidioidomycosis(San Joaquin Valley Fever)

Actinomycosis,Nocardiosis

Sporotrichosis

Histoplasmosis

14．DISEASES CAUSED BY PROTOZOA

Cutaneous Leishmaniasis

Mucocutaneous Leishmaniasis

15．DISEASES CAUSED BY VIRUSES

Variola,Varicella,Herpes Zoster,Herpes Simplex

Eczema Vaccinatum and Eczema Herpeticum(Kaposi＇s Varicelliform Eruption)

Molluscum Contagiosum

Verruca

Verruca Vulgaris

Verruca Plana

Verruca Plantaris

Condyloma Acuminatum

Lymphogranuloma Venereum(Lymphogranuloma Inguinale,Lymphopathia Venerea)

Milkers＇ Nodules

Ecthyma Contagiosum(Orf)

16．METABOLIC DISEASES

Lipoidoses

Systemic Lipoidoses with Increased Serum Lipids

Systemic Lipoidoses with Normal Serum Lipids

Purely Cutaneous Lipoidoses with Normal Blood Lipids

Amyloidosis

Primary Systemic Amyloidosis

Lichen Amyloidosus

Localized Nodular Amyloidosis

Calcinosis Cutis

Metastatic Calcification

Dystrophic Calcification

Gout

Porphyria

Myxedema

Generalized Myxedema

Circumscribed Myxedema

Lichen Myxedematosus

Scleredema Adultorum(Buschke)

Addison＇s Disease

Acanthosis Nigricans

Riehl＇s Melanosis,Melanodermatitis Toxica

Vitiligo

Hemochromatosis(Bronze Diabetes)

Ochronosis

Vitamin A Deficiency(Phrynoderma)

Pellagra

Vitamin C Deficiency(Scurvy)

17．SYSTEMIC DISEASES OF UNKNOWN CAUSE

Lupus Erythematosus

Chronic Discoid Lupus Erythematosus

Subacute Disseminated Lupus Erythematosus

Acute Systemic Lupus Erythematosus

Lupus Erythematosus Profundus

Lymphocytic Infiltration of the Skin(Jessner)

Dermatomyositis

Poikiloderma Atrophicans Vasculare

Scleroderma

Circumscribed Scleroderma(Morphea)

Systemic Scleroderma

Periarteritis Nodosa

Wegener＇s Respiratory Granulomatosis

Lethal Mid-line granuloma of the Face

Malignant Atrophic Papulosis(Degos)

18．EPIDERMAL TUMORS

Histogenesis and Classification of Epidermal Tumors

1．Tumors of the Surface Epidermis

Nevus Verrucosus

Seborrheic Keratosis(Verruca Senilis,Basal Cell Papilloma)

Epidermal Cyst,Sebaceous Cyst,Milium,Dermoid Cyst

Keratosis Senilis

Leukoplakia

Squamous Cell Carcinoma(Epidermoid Carcinoma)

Keratoacanthoma

Bowen＇s Disease

Erythroplasia of Queyrat

Paget＇s Disease

2．Tumors of the Epidermal Appendages

Nevus Sebaceus(Jadassohn)

Adenoma Sebaceum(Pringle)(Tuberous Sclerosis)

Senile Sebaceous Nevus(Senile Sebaceous Hyperplasia)

Fordyce＇s Disease

Apocrine-Gland Nevus

Hair Nevus

Sebaceous Adenoma

Syringocystadenoma Papilliferum(Nevus Syringocyst-adenomatosus Papilliferus)

Hidradenoma Papilliferum

Folliculoma(Hair-Follicle Tumor)

Sebaceous Epithelioma

Syringoma

Cylindroma

Apocrine Myo-epithelioma

Mixed Tumor of the Skin

Trichoepithelioma(Epithelioma Adenoides Cysticum,Multiple Benign Cystic Epithelioma)

Calcifying Epithelioma

Basal Cell Epithelioma

Eccrine Spiradenoma

Eccrine Poroma

Carcinoma of Sebaceous Glands

Carcinoma of Eccrine Sweat Glands

Carcinoma of Apocrine Glands

3．Metastatic Carcinoma of the Skin

Cutaneous Metastasis from Carcinoma of the Breast

Cutaneous Metastasis from Carcinomas Other Than Breast Carcinoma

19．MESODERMAL TUMORS

1．Tumors of Fibrous Tissue

Dermatofibroma,Histiocytoma(Sclerosing Hemangioma,Nodular Subepidermal Fibrosis)

Giant-Cell Reticulohistiocytoma

Giant-Cell Epulis

Keloid

Fibrosarcoma

Subcutaneous Fibrosarcoma

Dermatofibrosarcoma Protuberans

2．Tumors of Mucoid Tissue

Myxoma

Myxosarcoma

Mucous Cyst of the Skin

3．Tumors of Fatty Tissue

Nevus Lipomatosus Superficialis

Lipoma

Hibernoma

Liposarcoma

Malignant Hibernoma

4．Tumors of Nerve Tissue

Neuroma

Neurofibromatosis(von Recklinghausen＇s Disease)

Neurilemmoma

Cutaneous Meningioma

5．Tumors of Vascular Tissue

Hemangioma

Granuloma Pyogenicum

Senile Hemangioma

Angiokeratoma Mibelli

Angiokeratoma Corporis Diffusum

Nevus Araneus

Osler＇s Disease(Familial Hemorrhagic Telangiectasia)

Lymphangioma

Glomus Tumor

Hemangiopericytoma

Kaposi＇s Sarcoma(Multiple Idiopathic Hemorrhagic Sarcoma)

Hemangio-endothelioma

Postmastectomy Lymphangiosarcoma

6．Tumors of Muscular Tissue

Leiomyoma

Leiomyosarcoma

Granular Cell Myoblastoma

Malignant Granular Cell Myoblastoma

7．Tumors of Osseus Tissue

Osteoma Cutis

20．PIGMENTED NEVI AND MALIGNANT MELANOMA

Pigmented Nevus

Malignant Melanoma

Juvenile Melanoma

Lentigo

Mongolian Spot

Blue Nevus

21．LYMPHOMA AND MYELOSIS

Lymphoma

Stem-Cell Lymphoma

Reticulum-Cell Lymphoma

Lymphoblastic Lymphoma

Lymphocytic Lymphoma

Follicular Lymphoma(Brill-Symmers)

Hodgkin＇s Disease

Mycosis Fungoides

Generalized Exfoliative Dermatitis in Lymphoma

Herpes Zoster in Lymphoma

Lymphocytoma Cutis(Lymphadenosis Benigna Cutis;Spiegler-Fendt Sarcoid)

Myelosis

Plasmacytoma(Multiple Myeloma)

Erythremic Myelosis

GLOSSARY

INDEX