1 Origins and Principles of Translational Control M．B．Mathews．N．Sonenberg,and J．W．B．Hershey

Contents

Preface

2 Pathway and Mechanism of Initiation of Protein Synthesis J．W．B．Hershey and W．C．Merrick

3 The Protein Biosynthesis Elongation Cycle　W．C．Merrick　and J．Nyborg　

4 Comparative View of Initiation Site Selection Mechanisms　R．J．Jackson　

5 Mechanism and Regulation of Initiator Methionyl-tRNA Binding to Ribosomes　A．G．Hinnebusch　

6 Regulation of Ribosomal Recruitment in Eukaryotes B．Raught,A．-C．Gingras,and N．Sonenberg　

7 Translational Control of Developmental Decisions M．Wickens,E．B．Goodwin,J．Kimble,S．Strickland,and M．Hentze

8 ViraI Translational Strategies and Host Defense Mechanisms T．Pe'ery and M．B．Mathews　

9 Ribosomal Subunit Joining T．V．Pestova,T．E．Dever,and C．U．T．Hellen

10 Physical and Functional Interactions between the mRNA Cap Structure and the Poly(A)Tail A．Sachs

11 Translation Termination：It's Not the End of the Story E．M．Welch,W Wang,and S．W．Peltz

12 Genetic Approaches to Translation Initiation in Saccharomyces cerevisiae T．F．Donahue

13 Double-stranded RNA-activated Protein Kinase PKR R．J．Kaufman

14　Heme-regulated eIF2α Kinase J．-J．Chen

15 PERK and Translational Control by Stress in the Endoplasmic Reticulum D．Ron and H．P．Harding　

16 Regulation of Translation Initiation in Mammalian Cells by Amino Acids S．R．Kimball and L．S．Jefferson

17 Translational Control during Heat Shock R．J．Schneider

18 Translational Control by Upstream Open Reading Frames A．P．Geballe and M．S．Sachs

19　 Cellular Internal Ribosome Entry Site Elements and the Use of cDNA Microarrays in Their Investigation　M．S．Carter,K．M．Kuhn．and．P．Sarnow　

20 Iranslational Control and Cancer J．W．B．Hershey and S．Miyamoto

21 Translational Control of Ferritin Synthesis T．A．Rouault and J．B．Harford

22 Translational Control of TOP mRNAs O．Meyuhas and E．Hornstein

23 S6 Phosphorylation and Signal Transduction S．Fumagalli and G．Thomas

24 Control of the Elongation Phase of Protein Synthesis C．Proud

25 Programmed Translational Frameshifting,Hopping,and Readthrough of Termination Codons P．J Farabaugh,Q．Qian,and G．Stahl

26 Recoding UGA as Selenocysteine M．J．Berry

27 Influence of Polyadenylation-induced Translation on Metazoan Development and Neuronal Synaptic Function J．D．Richter

28 Interaction of mRNA Translation and mRNA Degradation in Saccharomyces cerevisiae D．C．Schwartz and R．Parke r

29 Destabilization of Nonsense-containing Transcripts in Saccharomyces cerevisiae A．Jacobson and S．W．Peltz　

30 Nonsense-mediated RNA Decay in Mammalian Cells：A Splicing-dependent Means to Down-regulate the Levels of mRNAs That Prematurely Terminate Translation L．E．Maquat

31 Translation Initiation on Picornavirus RNA G．J Relsham and R．J．Jackson

32 Adenovirus Inhibition of Cellular Protein Synthesis and Preferential Translation of Viral mRNAs R．J．Schneider

33 Reovirus Translational Control A．J．Shatkin

34 Translational Reprogramming during Influenza Virus Infection S．-L．Tan,M．Gale,Jr．,and M．G．Katze

35 Translational Control in Poxvirus-infected Cells B．L．Jacobs

36 Nontranslational Functions of Components of the Translational Apparatus　T．G． Kinzy and E．Goldman

Index