PART 1

Introduction

INTRODUCTION TO CLINICAL PHARMACOLOGY AND RATIONAL THERAPEUTICS David W.Nierenberg, Kenneth L.Melmon

PART 2

Drug Therapy of Common Diseases: Problem-Based Therapeutic Decisions

CHAPTER 1

CARDIOVASCULAR DISORDERS

Hypertension Brian B.Hoffman, S.George Carruthers

Hypotension David Robertson

Coronary Artery Disease Thomas Michel, Mark S.Weinfeld

Acute Myocardial Infarction Christopher P.Cannon, Peter H.Stone

Heart Failure J.Malcolm O.Arnold

Arrhythmias Dan M.Roden

Peripheral Arterial Occlusive Disease Thomas L.Whitsett

Venous Thromboembolic Disease Brian G.Birdwell, Thomas L.Whitsett

Adverse Effects of Cardiovascular Drugs on the Cardiovascular System Stanley Nattel

CHAPTER 2

Introduction and General Approach to Therapy John A.Abisheganaden, Homer A.Boushey

Obstructive Lung Diseases: Treatment John A.Abisheganaden, Homer A.Boushey, Stephen I.Rennard

Asthma John A.Abisheganaden, Homer A.Boushey

Chronic Obstructive Pulmonary Disease Stephen I.Rennard

Cystic Fibrosis Moira L.Aitken, Mark Tonelli

Pneumonia Michael S.Niederman

Pulmonary Vascular Disease Sean P.Gaine

Idiopathic Pulmonary Fibrosis Naseema B.Merchant, Paul W.Noble

Drug-Induced Lung Disease Naseema B.Merchant, Paul W.Noble

CHAPTER 3

GASTRO, NTESTINAL DISORDERS Gabriel Garcia

CHAPTER 4

HEPATR DISORDERS AND THE INFLUENCE OF LIVER FGNCIION ON DRUG DISPOSITION Gabriel Garcia

CHAPTER 5

? Elizabeth M.Ross, Irwin H.Rosenberg

CHAPTER 6

? D.Craig Brater

CHAPTER 7

?

Headache Thomas N.Ward

Seizures Richard S.McLachlan

Cerebrovascular Diseases Arturo Tamayo, Vladimir Hachinski

Parkinson s Disease David J.Coffey

Dementia Lawrence R.Jenkyn

Multiple Sclerosis: Current Treatment G.P.A.Rice,George C.Ebers

Myasthenia Gravis Michael W.Nicolle

Drug-Induced Neurologic Disorders B.M.Demaerschalk, P.E.Cooper

CHAPTER 8

PSYOHATRIC DISORDERS Leo E.Hollister

CHAPTER 9

ENDC CRINE AND MEFABOHC DISORDERS

Diabetes Mellitus Jeffrey W.Miller, Fredric B.Kraemer

Dyslipidemias Fredric B.Kraemer, Jeffery W.Miller

Adrenal Steroids Jeffrey W.Miller

Thyroid Disease Jeffrey W.Miller

Reproductive Steroids Jeffrey W.Miller

Hypothalamic Hormone Therapy Steven A.Lieberman, Andrew R.Hoffman

CHAPTER 10

CONNECTIVE TISSUE AND BONE DISORDERS

Rheumatic Disorders Richard Day, David Quinn, Kenneth Williams, Malcolm Handel, Peter Brooks

Osteoporosis Robert Marcus

CHAPTER 11

DERMATOLOGIC DISORDERS Christopher M.Barnard, Marc E.Coldyne

CHAPTER 12

HEM TOIOGIC DISORDERS Richard Lin, Zhuo-Wei Hu

ONCOLOGIC DISORDERS Joseph R.Bertino, Owen A.O Connor

CHAPTER 13

CHAPTER 14

INFECTIOUS DISORDERS Thomas J.Marrie,Claire Touchie,B.Lynn Johnston, Kevin R.Forward, Kathryn L.Slayter, Spencer Lee, Paul Hoffman

CHAPTER 15

CONSCIOUS SEDATION AND PAN Mervyn Maze ,John C.Hunter, Raymond R.Gaeta

CHAPTER 16

TREATMENT IN THE INTENSIVE CARE UNIT David J.Liepert, Ronald G.Pearl

CHAPTER 17

SUBSTANCE ABUSE: DEPENDENCE AND TREATMENT Lori D.Karan, Neal L.Benowitz

CHAPTER 18

POISONING Lewis S.Nelson, Lewis R.Goldfrank

PART 3

Core Topics in Clinical Pharmacology

DRUG THERAPY IN PREGNANT AND BREAST-FEEDING WOMEN Peter C.Rubin, Jane M.Rutherford

CHAPTER 19

CHAPTER 20

DRUG THERAPY IN PEDIATRIC PATIENTS Ronen Loebstein, Sunita Vohra, Gideon Koren

CHAPTER 21

GERIATRIC PHARMACOLOGY Robert E.Vestal, Jerry H.Gurwitz

CHAPTER 22

PHARMACOGENETICS Urs A.Meyer

CHAPTER 23

CLINICAL PHARMACOKINETICS AND PHARMACODYNAMICS Daniel S.Sitar

CHAPTER 24

ADVERSE DRUG REACTIONS David W.Bates, Lucian Leape

DRUG INTERACTIONS James M.Wright

CHAPTER 25

CHAPTER 26

WRITING PRESCRIPTIONS Terrence F.Blaschke

CHAPTER 27

DRUG DISCOVERY AND DEVELOPMENT Richard D.Mamelok

CHAPTER 28

RISK ANALYSIS APPLIED TO PRESCRIPTION DRUGS John Urquhart

CHAPTER 29

THE CLINICIAN S ACTIONS WHEN N=1 Gordon Guyatt, David L.Sackett

CHAPTER 30

INFORMATION ABOUT DRUGS: A CLINICAL EPIDEMIOLOGIC APPROACH TO THERAPEUTICS Brian L.Strom

Appendix

Index