Part I Mechanisms of Restenosis and Alternative Treatments

1.Restenosis Following Angioplasty: Scope of the Problem[Spencer B. King, III, MD]

Foreword:Martin B. Leon, MD

Preface

Preface(Adopted and Modified from the first edition)

Contributors

2.Restenosis and Remodeling[Robert S. Schwartz, MD and David R. Holmes, Jr., MD]

3.Adventitial Remodeling Associated with Postangioplasty Restenosis[Josiah N. Wilcox. PhD nad Neal A. Scott, MD. PhD]

24.Local Delivery of Radionuclides to Prevent Restenosis[Ron Waksman, MD, FACC, Rosanna C. Chan. PhD. Lisa R. Karam, PhD, and Brian E. Zinmmerman, PhD]

4.Animal Models to Study Restenosis[Keith A. Robinson,PhD］

5.Artetial Remodeling as a Mechanism of Restenosis Following Intetventional Coronary Procedures: Evidence from Serial Intravascualr Ultrasound Studies[Gary S. Mintz, MD, Jeffrey J. Popma, MD, Augusto D. Pichard. MD, Kenneth M. Kent,MD, Lowe

6. Antirestenosis Alternatives for the Next Millennium[Michael J.B. Kutryk MD. PhD.FRCPC and Patrick W. Serruys MD,PhD, FACC, FESC]

Part II Radiation Biology and Vascular Pathology

7.The Basic Radiobiology of Intravasular Irradiation [Eric J. Hall, D Phil, DSc, FACR,Richard C. Miller. PhD. and David J. Brenner. PhD. DSc]

8. Radiation Injury to Blood Vessels[Luis F. Fajardo, L.G. MD]

9. Radiation Biology Concepts for the Use of Radiation to Prevent Restenosis[James B. Mitchell. PhD]

10.Radiation Inhibition versus Induction of Vascular Restenosis: The Role of the Monocyte-Derived Macrophage Philoip Rubin. MD, Jacqueline P. Williams. PhD, Jacob Finkelstein, PhD,Richard Pomerantz,MD,and Paul Okunieff, MD]

11.Mechanisms by Which Radiation May Prevent Restenosis:Inhibition of Cell Proliferation and Vascular Remodeling[Josiah N. Wilcox, PhD, Spencer B. King. MD,and Ron Wsksman, MD, FACC]

12.Potential Roles for Nitric Oxide and Transforming Growth Factor-β1 in Endovascualr Brachytherapy[Yoram Vodovotz, PhD and Ron Wahsman, MD. FACC]

Part III Radiation Physics and Dosimetry for Vascular Brachytherapy

13.Dosimetry of Sealed Beat Particle Sources[Chiristopher G. Soares.PhD]

14. Basic Physics of Gamma Isotopes[Shirish K. Jani, PhD]

15. Intravascular Brachytherapy Physics: Review of Radiation Sources and Techniques[Howard I. Amols. PhD]

16.Intravascular Brachytherapy: A Health Physics Perspective[Stephen Balter, PhD]

Part IV Radiation for Restenosis in Animal Models

17.External Beam Irradiation, Stent Injury, and Neointimal Hyperplasia: Results in a Porcine Model[Robert S. Schwartz, MD, FACC. Thomas M. Koral PhD. Jean Gregoire, MD, Myung Ho Jeong. MD. PhD. William D. Edwards, MD, FACC, Allan R, Camrud,

18. Comparison of Endovascular and External Beam Lrradiation in the Prevention of Restenosis[Monique M.H. Marijianowski, PhD, Keith Robinson, PhD, and Ian R. Crocker, MD]

19.External Beam Ionizing Irradiation for the Prevention of Restenosis Past and Future[Morris Mosseri, MD and Zeev Weshier, MD]

20.Intracoronary Ganma Irradiation Studies in the Swine Model of Restenlsis[Ron Waksman, MD, FACC]

21.Intra-Atrerial Beta Irradiation and the Prevention of Neointimal Hyperplasia in a Hypercholesterolemic Rabbit Restenosis Model[Vitali Verin, MD, Youri Popowski, MD, Philip Urban, MD, Jean Belenger, Mirelippe Redard, Manuel Costa, Marie-C

22.Endovascular Beta Radiation in the Swine Model[Ron Waksman, MD, FACC]

23.Endovascular Radiation with Beta and Gamma Sources in the Porcine Model[Albert E. Raizner, MD, Wojciech Mazur, MD, and M, Nadir Ali, MD]

25.Intravasular Red Light Therapy: Long-Term Results from the Human Clinical Trial[Nicholas N. Kipshidze, MD, PHD, Ican DeScheerder, MD, PhD, Upendra Kaul, MD, Harry Sahota, MD and Michael H, Keelan Jr., MD]

Part V Stents and Radiation

26.Dosimetric Considerations and Dose Measurement Analysis of Phosphorus 32 Beta-Emitting Stents: A Review[Charles W, Coffey, II, PhD, Dennis M. Duggan, PhD, and Robin C. Reddick, PhD]

27.Radioactive Stents; The European Experience[Christoph Hehrlein, MD]

28.Long-Term Effects of Phosphorus 32 Radioactive Stents in Experimental Models[Andrw J, Carter, DO, FACC]

29.Pathology of Radioactive Stents[Renu Virmani, MD, Andrew J, Carter. Do, Russ M, Jones, and Andrew Farb, MD]

30.Catheter-Based Radiation Therapy in Stented Arteries[Ron Waksntan, MD, FACC]

Part VI Vascular Radiation and Peripheral Vascular Disease

31.Peripheral Vafscular Radiation Therapy: Problems Related to Technical Ap-plications[Louis G. Marlin, MD]

32.Restenosis in Peripheral Vascular Disesae[Alan B. Lumsden, M. Julia MacDonald, and Changyi Chen]

33.Intravascular Irradiation Therapy[Dieter D. Liermann, R, Bauernsachs, Bernard Schopohl, and H.D. Bottcher]

34.Peripheral Vascular Brachytherapy[Ron Waksman, MD, FACC]

35.External Radiation Therapy for Patients with Arteriovcenous Dialysis Shunts[Suhrid Parikh, MBBS, MS, MCH and Dattatreyudu Nori, MD, FACR]

Part VII Endovascular Radiation Clinical Trials in Coronary Arteries

36.Intracoronary Radiation Therapy for Restenosis: The Clinical Trials[Ron Waksman, MD, FACC]

37. Intracoronary Gamma Radiation Following Balloon Angioplasty: The Venezuelan Experience[Jose A. Condado, MD, Ron Waksman, MD, FACC, Orlando Guraiel, MD, Harry Acquatella, MD, Carlos Calderas, MD, Ian R. Crocker, MD, and Samuel F. Liprie,

38.Intracoronary Gamma Radiation and Stents for Restenotic Lesins: The Scripps Clinic Experience[Paul S, Teirstein, MD, Vincent Massullo, MD, Shirish Jani, PhD, and Prabhakar Tripuraneni, MD]

39.Clinical Restenosis Trials Using Beta Energy Radiation[Spencer B. King III, MD and Raoul Bonan, MD]

40.Lessons from the Feasibility Radiactive(IRIS) Stent Trials[Tim A. Fischell, MD, Andrew Carter, DO, Malcolm Foster, MD, Robert E. Fischell, ScD, and David R. Fischell, PhD]

Part VIII Systems for Endovascular Radiation Therapy

41.Best: Manually Loaded Iridium 192 Ribbon[Shirish K. Jani, PhD, Gerard B. Huppe, MS, Vincent Massullo, Md, Prabhakar Tripuraneni, MD, and Paul Teirstein, MD]

42.NovosteTM Beta-CathTM Intracoronary Beta Radiation System[Richard A. Hillstead]

43.Nucletron Afterloading Technology for Brachytherapy: The Peripheral System[Edgar G. Loffter, PhD and Frits M. van Krieken, MSc, PhD]

44.The Guidant Coronary Source Wire System[Albert Raizner, MD, Richard V, Calfee, PhD, M. Nadir Ali, MD, Anthony J, Bradshaw, BS, ID, and Robert P, Eno, MBA]

45.Use of Liquid-Filled Balloons for Coronary Irradiation[Judah Weinberger, MD, PhD and F.F.(Russ) Knapp, Jr., PhD]

46.Clinical Trials Using Beta Energy Radiation: Experimental and Clinical Experience with Schneider-Sauerwein Intravascular Radiation System[Vitali Verin, MD and Youri Popowski, MD]

47.The AnigioradTM Gamma Wire System[David P. Faxon, MD and Samuel F. Liprie, PD (Nuc)]

48.Intravascular Soft X-Ray Therapy[Victor Chornenky, PhD]

Part IX Regulatory and Health Care Milieu Issues

50.Radiation Safety Requirements for Vascular Radiotherapy in the Catheteri-zation Laboratory[Billy G. Bass, PhD]

51.Regulatory Considerations for Approval of Vascular Radiation Studies in the United States[Tara A. Ryan, MS, MBA]

52.The Economics of Restenosis: Implications for Brachytherapy[William S Weintraub, MD]

Index